Chesapeake is a village in Lawrence County, Ohio, United States. The population was 745 at the 2010 census. It lies across the Ohio River from Huntington, West Virginia, at the mouth of Symmes Creek.
A bridge across the Ohio River connects Chesapeake to Huntington's downtown area. At one time, this was the only bridge connection across the Ohio River linking Ohio to Huntington. In recent years, bridges across the Ohio River connecting Ohio to Huntington's East and West sides have been built.
Chesapeake is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area(MSA). As of the 2000 census, the MSA had a population of 288,649.